Stem cells are able to regrow lost teethStem cells were discovered in 1998 in humans. They are undifferentiated cells, able to divide and differentiate into other types of cells capable of building up tissues like muscle, neuron, veins... Stem cells originate from two main sources: embryos which ensure its growth and development, and adult body tissues.
Thanks to these properties, the stem cells can be used to regenerate us, recreate destroyed tissues and treat a lot of diseases that were incurable like Alzheimer. Dental stem cells have an origin close to all cells that will build neurons, brain, nerves, spinal cord. In short, these cells are able to produce all cell types. That's why now, there are stem cell banks that allow us to store our stem cells for later cell therapy.
Stem cells for teeth regrowth: It is possible ?The recipe for growing teeth seems simple. The image above shows the formation of teeth from stem cells in a mouse. A new technique pioneered in the Tissue Engineering and Regenerative Medicine Laboratory of Dr. Jeremy Mao, Edward V. Zegarelli Professor of Dental Medicine, and a professor of biomedical engineering at Columbia University, could make tooth loss a thing of the past.
The principle is to cultivate stem cells, an idea that is not new and that has raised hopes and experiments for several years. But, the scientists did it, and it was worth it... Biologists first took dental tissue from a young mouse embryo.
Dental stem cells were cultured and provided with growth factors for 5-7 days. The biologists then implanted it in the upper jaw of an adult mouse whose teeth was previously extracted. After 36 days, the new teeth had pierced the gum and, after 49 days, had reached normal size and, well aligned with the teeth of the lower jaw, allowed perfect chewing. The innervation and vascularization have been well-established, which will give the tooth a sensitivity to pressure and heat, something impossible with prosthesis or implant. The teeth formed from the stem cells are perfectly identical to the natural teeth. But, could this technique be applied in humans? Yes, the technique could be applied in humans. The missing tooth will be formed from stem cells taken from the person, since we know now that such cells are found in adults too. The scientific success is very interesting, but, if the operation is actually possible in humans, what remains to prove, the technique is still far from the dentists ..
Treat cavities or broken teeth from stem cells: Is it possible ?Stem cells of the milk teeth are more efficient than those of adults, hence the interest of keeping preciously the baby teeth of children because it could save their lives later. Sometimes children fall, bump and break a tooth. If the fracture has touched a permanent tooth, it can die which results in the cessation of circulation and loss of sensitivity; blood circulation in the tooth will stop causing loss of sensitivity. With the new cell therapy, no need to worry, it is enough to implant stem cells in the injured site, so that the tooth is alive again. An experiment was carried out by Chinese and American researchers in which 40 children participated. One of their permanent incisors was broken, but they still had baby teeth. For children treated with stem cells, tooth root was more likely to grow, dentin (located under the enamel) was thicker, vascularization and innervation were formed.
Before treatment, the children had little sensation on the broken tooth. But one year after the treatment, the children treated with stem cells found sensations: the tooth is alive again. So, it seems that the end of the composite, amalgam and other inorganic restorations is approaching.
Tomorrow, the stem cells will take over with better rendering and efficiency, low price and a short treatment time.
It can be used not only in dentistry, but also to treat diseases of the blood and the immune system, or to rebuild the blood system after treatment of certain cancers. Diseases that have been incurable, which is no longer the case today, have been cured thanks to the new cellular therapy, including neurological diseases (Parkinson's, Alzheimer's ...), age-related muscle degeneration, diabetes or even spinal cord injuries.